Irf4 pathway
WebExpression of IRF4 and IRF8 is restricted to the lymphoid and myeloid lineages of the immune system ( 4 ), whereas they are crucial for B lymphocyte development and Th cell differentiation. In addition to a pro-inflammatory role, IRF5 is … WebInterferon regulatory factor 4 (IRF4) has critical roles in immune cell differentiation and function and is indispensable for clonal expansion and effector function in T cells. Here, we demonstrate that the AKT pathway is impaired in murine CD8 + T cells lacking IRF4.
Irf4 pathway
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WebJul 16, 2024 · Foxp3-expressing regulatory T (Treg) cells can suppress the activity of various types of immune cells and play key roles in the maintenance of self-tolerance and in the regulation of immune responses against pathogens and tumor cells. Treg cells consist of heterogeneous subsets that have distinct phenotypes and functions. Upon antigen … WebThe 27.5 mile Joe Louis Greenway is a planned biking and walking trail that extends from the Detroit Riverfront to Highland Park, Dearborn, and Hamtramck. It also includes connectors …
WebApr 19, 2024 · Here we explore the impact of type I interferon (IFNβ) on macrophage metabolism and its broader impact on cytokine signaling pathways. We find that IFNβ … WebApr 30, 2009 · IRF4 (also known as pip, MUM1, LSIRF, NFEM5, and ICSAT) is an IRF-family member that is restricted in expression to the immune system, a property it shares with its closely related family member IRF8. IRF4 and IRF8 have evolved as critical mediators of lymphoid-, myeloid-, and dendritic-cell development ( 1 – 5 ).
WebJP7239597B2 JP2024545734A JP2024545734A JP7239597B2 JP 7239597 B2 JP7239597 B2 JP 7239597B2 JP 2024545734 A JP2024545734 A JP 2024545734A JP 2024545734 A JP2024545734 ... IRF4 is an essential regulatory component at various stages of B cell development. In early B cell development, IRF4 functions alongside IRF8 to induce the expression of the Ikaros and Aiolos transcription factors, which decrease expression of the pre-B-cell-receptor. [9] See more Interferon regulatory factor 4 (IRF4) also known as MUM1 is a protein that in humans is encoded by the IRF4 gene, located at 6p25-p23. IRF4 functions as a key regulatory transcription factor in the development of … See more IRF4 is a transcription factor belonging to the Interferon Regulatory Factor (IRF) family of transcription factors. In contrast to some other IRF family members, IRF4 expression is not initiated by interferons; rather, IRF4 expression is promoted by a variety of bioactive … See more IRF4 has been shown to interact with: • Aiolos, • BATF3, • Blimp-1, See more • FactorBook IRF4 • IRF4+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) This article … See more In melanocytic cells the IRF4 gene may be regulated by MITF. IRF4 is a transcription factor that has been implicated in acute leukemia. This gene is strongly associated with pigmentation: sensitivity of skin to sun exposure, freckles, blue eyes, and brown hair color. A … See more • Interferon regulatory factors See more • Mamane Y, Sharma S, Grandvaux N, Hernandez E, Hiscott J (January 2002). "IRF-4 activities in HTLV-I-induced T cell leukemogenesis". Journal of Interferon & Cytokine Research. 22 (1): 135–143. doi:10.1089/107999002753452746. PMID 11846984 See more
WebThe significant enrichment of Th17 cell differentiation found in pathway analyses highlight the potential importance of this pathway in JIA etiology. Four candidate genes at genome‐wide significant loci ( SMAD2 , IL1RAP , IL6ST , and …
WebJun 21, 2024 · The TCR pathways leading to IRF4 are unclear, and our data shows for the first time that downstream of the TCR and ITK, the Ras/MAPK pathways leads to IRF4 … chinese takeaway audleyWebFurther studies are required to elucidate the potential association between IRF4 expression and other inflammatory signaling pathways. In conclusion, our results indicate that IRF4 deficiency drives macrophage polarization toward M1 phenotype and increases the production of pro-inflammatory cytokines, which finally results in worsen ... grandview hospital medical records fax numberWebNov 7, 2024 · Protein kinase B (Akt)/STAT6-JMJD3/IRF4 pathway was found crucial for M2 differentiation of dMϕ induced by receptor activator of nuclear factor-κB ligand (RANKL) at the maternal-fetal interface in vitro and in vivo, and the activation of Akt/STAT6-JMJD3/signaling induced decidual M2 macrophage polarization to promote smooth … grandview hospital npi numberWebIRF4. Interferon regulatory factor 4 (IRF4) also known as MUM1 is a protein that in humans is encoded by the IRF4 gene, [5] [6] [7] located at 6p25-p23. IRF4 functions as a key regulatory transcription factor in the development of human immune cells. [8] [9] The expression of IRF4 is essential for the differentiation of T lymphocytes and B ... chinese takeaway aston fields bromsgroveWebIRF8 and IRF4 are also involved in the regulation of B and T-cell development at multiple stages. IRF8 and IRF4 function redundantly to drive common lymphoid progenitors (CLPs) … grandview hospital occupational healthWebSep 1, 2006 · IRF4 and IRF8 can function as transcriptional repressors when bound to an ISRE motif but as transcriptional activators when bound to an ETS/ISRE composite DNA … chinese takeaway aylesburyWebIRF8 and IRF4 are also involved in the regulation of B and T-cell development at multiple stages. IRF8 and IRF4 function redundantly to drive common lymphoid progenitors (CLPs) to B-cell lineage. IRF8 and IRF4 are also required in the regulation of germinal center (GC) B cell differentiation. Role in Diseases [ edit] grand view hospital pa