WebBiology questions and answers. A miRNA named lin-4 is important for regulation of development in C. elegans. It regulates the activity of the lin-14 gene, but without causing … WebMar 24, 2024 · The mitochondrial unfolded protein response (UPR mt) is a stress response pathway that regulates the expression of mitochondrial chaperones, proteases, and other proteins involved in protein folding and degradation, thereby ensuring proper mitochondrial function.In addition to this critical function, the UPR mt also plays a role in other cellular …
A Developmental Timing MicroRNA and Its Target Regulate Life …
WebFeb 14, 2012 · In C. elegans, let-7 miRNA regulates developmental timing events during the L4-to-adult transition. let-7 down-regulates its target genes, such as lin-41 and hbl-1, and this releases their repression of LIN … WebThis suggests that lin-4 down-regulates lin-14 transla- tion by forming multiple RNA duplexes with the lin-14 mRNA (Wightman et al. 1993). Here we show that multiple elements in the lin-14 3' UTR are conserved between C. briggsae and C. elegans, but that the lin-4 complementary elements account for can a right angle be equilateral
Autoregulation of lin-4 microRNA transcription by RNA activation …
WebApr 11, 2024 · The crosstalk and feedback within the heterochronic pathway is remarkable. A recent example of this is the demonstration that lin-4 both directly represses and … WebApr 18, 2006 · DAF-16 Is Required for Transcriptional Repression of the microRNA lin-4 during L1 Arrest (A–C)Worms carrying an integrated lin-4::YFP reporter were hatched in the presence (A) or absence (B and C) of E. coli OP50. In wild-type larvae, strong expression is visible everywhere except the four gonadal cells 12 hr after hatching with food (A), but ... WebThe discovery of the first microRNA (miRNA), lin-4, in 1993 by the Ambros and Ruvkun groups in Caenorhabditis elegans (1, 2) has revolutionized the field of molecular biology. Years before, lin-4 was characterized by the … fishflies comic